Figure 3.

Clinical conditions over time following peroral C. coli infection of aged conventional IL-10^-/- mice. Aged IL-10^-/- mice were perorally challenged with C. coli (black symbols) on day (d) 0 and d1 or received vehicle (mock controls; white symbols). Clinical conditions of mice were surveyed over time post-infection applying a standardized clinical scoring system assessing (A,B) overall gross clinical conditions, (C,D) abundance of fecal blood and (E,F) stool consistency. Absolute clinical scores (A,C,E) and score-positive animals out of the total number of analyzed mice (in %; B,D,F) are indicated. Data were pooled from four independent experiments.