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. 2020 Jun 29;12(7):1935. doi: 10.3390/nu12071935

Table 10.

Hempseed phenylpropionamides and their biological effect.

Compound Biological Effect Ref.
N-trans-caffeolyltyramine Strong in vitro scavenging DPPH radical and ORAC antioxidant activity;
LDL protection against in vitro oxidation;
In vitro AChE and arginase inhibitory activity;
In vivo anti-neuroinflammatory action;
In vitro prevention of H2O2-induced cell death.		 [100]
[103]
[104]
[107]
[111]
N-trans-feryoryltyramine In vitro scavenging DPPH radical activity;
In vivo anti-neuroinflammatory action.		 [103]
[111]
N-trans-caffeolyoctopamine In vivo anti-neuroinflammatory action. [111]
N-trans-cumaroyltyramine In vivo anti-neuroinflammatory action. [111]
Cannabisin A In vitro scavenging DPPH radical activity;
In vivo anti-neuroinflammatory action.		 [103]
[111]
Cannabisin B Strong in vitro scavenging DPPH radical and ORAC antioxidant activity;
LDL protection against in vitro oxidation;
In vitro arginase inhibitory activity.		 [100]
[104]
[111]
Cannabisin C In vitro scavenging DPPH radical activity;
In vivo anti-neuroinflammatory action.		 [103]
[111]
Cannabisin D In vitro scavenging DPPH radical activity;
In vivo anti-neuroinflammatory action.		 [103]
[111]
Cannabisin E In vivo anti-neuroinflammatory action [111]
Cannabisin F In vitro scavenging DPPH radical and ORAC antioxidant activity;
In vivo anti-neuroinflammatory action;
In vitro inhibition of the NFκB inflammatory pathway, activation of Nfr-2 antioxidant pathway and upregulation of SIRT1.		 [104]
[110]
[111]
Cannabisin M In vitro scavenging DPPH radical activity;
In vivo anti-neuroinflammatory action.		 [103]
[111]
Isocannabisin N In vivo anti-neuroinflammatory action [111]
Grossamide In vitro inhibition of the NFκB inflammatory pathway.
In vivo anti-neuroinflammatory action;		 [109]
[111]
3,3′-demethyl-grossamide In vitro scavenging DPPH radical activity;
In vitro AChE inhibitory activity;
In vivo anti-neuroinflammatory action.		 [103]
[111]
3,3′-demethylheliotropamide In vitro AChE and arginase inhibitory activity. [103]
Sativamides A In vitro reduction of ER stress-induced cell death. [106]
Sativamides B In vitro reduction of ER stress-induced cell death. [106]
4-((E)-p-coumaroylamino)butan-1-ol In vitro inhibition of TNF-α release. [105]
Cumaroylaminobutanol glucopyranoside In vitro inhibition of TNF-α release;
In vitro inhibition of the NFκB inflammatory pathway and activation of Nfr-2 antioxidant pathway.		 [105]
[108]