Table 3. Difference in Seizure Reduction With the 3 Treatment Strategiesa,b.
| Comparison between interventions | Per-protocol analysis | Intention-to-treat analysis | ||
|---|---|---|---|---|
| Median (95% CI) | Mean (95% CI) | Median (95% CI) | Mean (95% CI) | |
| KD-MAD | −10 (−26 to 5) | −12 (−28 to 3.2) | −21 (−29 to 3) | −14 (−28 to 0.61) |
| KD-LGIT | −7 (−17 to 10) | −5.7 (−20 to 8.4) | −12 (−21 to 7) | −8.1 (−22 to 5.5) |
Abbreviations: KD, ketogenic diet; LGIT, low glycemic index therapy; MAD, modified Atkins diet.
a
In both the per-protocol and intention-to-treat analyses, the lower limit of the 95% CI of the median difference and mean difference in seizure reduction between MAD and KD, as well as between LGIT diet and KD, breached the noninferiority margin of −15 percentage points.
b
Data are given as percentage points.