Figure 3.

Sample storage stability and temporal trends in total antibody levels for the test panel of oral bacteria. (A) IgG response to Protein A (10 pg/mL) in 39 samples representing 39 of the 43 study years. Each sample consisted of 12 pooled plasma samples from the year the pooled sample represented. (B) Total antibody content of the panel of test bacteria in plasma samples collected from 1976 to 2018 from 30-year old men, and (C) from 1987 to 2017 from 50-year-old men and women. Each dot represents an individual subject and the lines indicate the trend from linear regression and 95% CI.