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. 2020 Jun 30;12(7):1946. doi: 10.3390/nu12071946

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Hepatocarcinoma (HCC) development by the concurrent diethylnitrosamine (DEN) injection and thioacetamide (TAA) administration to 6 weeks old C57BL/6 mice. (A) Impact of protease inhibitors (PIs) in percent survival of HCC developing mice. (B) Changes in liver to body weight (BW) ratio and (C) Variations in body weight gain of high fat diet-fed animals receiving PIs. (D) Influence of feeding PIs in the intrahepatic accumulation of nodes of mononuclear cells in DEN/TAA-treated mice administered with PIs. (E) Serum levels of bioactive hepcidin peptide concentration. (F) Hepatic changes in myeloperoxidase activity (MPO) in liver samples of HCC developing mice. * Indicates statistical differences (Tukey–Kramer’s test, p < 0.05) to DEN/TAA-treated animals not receiving PIs.