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. 2020 Jul 15;8(7):215. doi: 10.3390/biomedicines8070215

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The absence of SHIP1 expression in colorectal cancer is linked to microsatellite instability. (a,b) Immunohistochemistry-scored SHIP1 expression was correlated with expression of MLH1 and MSH2 as markers for microsatellite instability (p > 0.0001, each). (c) Leukocyte normalized SHIP1 mRNA expression from TCGA was analyzed for association with microsatellite status (p = 0.0012). (d,e) Immunohistochemistry-scored SHIP1 expression was correlated with the expression of nuclear and membranous β-Catenin (p > 0.0001 and p = 0.0022, respectively). (f) Leukocyte normalized SHIP1 mRNA expression was analyzed for association with methylation subtypes (p < 0.0001). (g) Leukocyte normalized SHIP1 mRNA expression was classified into low SHIP1 expression (low quartile) and high (upper three quartiles), and hierarchical clustering was performed, showing enrichment of microsatellite instability markers.