Table 1.
Gene expression profile of 57 genes belonging to the “Extracellular Matrix and Adhesion Molecules” pathway analyzed using real-time PCR after 24 h of treatment with mycophenolate.
| Gene | Fold Change | Gene Function |
|---|---|---|
| CD44 | 1.56 | Cell-Cell Adhesion (MIM:107269) |
| CDH1 | 4.62 | Cell-Cell Adhesion (MIM:192090) |
| COL1A2 | 2.20 | Collagens and Extracellular Matrix Structural constituent (MIM:192090) |
| COL2A1 | 1.71 | Collagens and Extracellular Matrix Structural constituent (MIM:120140) |
| COL3A1 | 1.71 | Collagens and Extracellular Matrix Structural constituent (MIM:120180) |
| COL4A1 | 3.43 | Collagens and Extracellular Matrix Structural constituent (MIM:120130) |
| COL5A1 | 1.31 | Collagens and Extracellular Matrix Structural constituent (MIM:120215) |
| COL6A1 | 1.69 | Collagens and Extracellular Matrix Structural constituent (MIM:120220) |
| COL7A1 | 0.74 | Collagens and Extracellular Matrix Structural constituent (MIM:120120) |
| COL8A1 | 2.54 | Collagens and Extracellular Matrix Structural constituent (MIM:120251) |
| COL9A1 | 1.42 | Collagens and Extracellular Matrix Structural constituent (MIM:120210) |
| COL10A1 | 2.10 | Collagens and Extracellular Matrix Structural constituent (MIM:120110) |
| COL11A1 | 1.95 | Collagens and Extracellular Matrix Structural constituent (MIM:120280) |
| CTNNA1 | 2.19 | Cell Adhesion Molecule (MIM:116805) |
| CTNNB1 | 2.36 | Cell Adhesion Molecule (MIM:116806) |
| CTNND2 | 0.95 | Cell Adhesion Molecule (MIM:604275) |
| FN1 | 1.03 | Cell Adhesion Molecule (MIM:135600) |
| HAS1 | 1.86 | Transmembrane Receptor (MIM:601463) |
| ILF3 | 1.73 | Transmembrane Receptor (MIM:603182) |
| ITGA1 | 3.72 | Transmembrane Receptor (MIM:192968) |
| ITGA2 | 5.30 | Transmembrane Receptor (MIM:192974) |
| ITGA3 | 3.04 | Transmembrane Receptor (MIM:605025) |
| ITGA4 | 1.71 | Transmembrane Receptor (MIM:192975) |
| ITGA5 | 2.82 | Transmembrane Receptor (MIM:135620) |
| ITGA6 | 1.84 | Transmembrane Receptor (MIM:147556) |
| ITGA7 | 4.81 | Transmembrane Receptor (MIM:600536) |
| ITGA8 | 1.82 | Transmembrane Receptor (MIM:604063) |
| ITGB1 | 2.22 | Transmembrane Receptor (MIM:135630) |
| ITGB2 | 0.91 | Transmembrane Receptor (MIM:600065) |
| ITGB4 | 0.59 | Transmembrane Receptor (MIM:147557) |
| ITGB5 | 1.46 | Transmembrane Receptor (MIM:147561) |
| LAMA1 | 1.30 | Basement Membrane Constituent (MIM:150320) |
| LAMA2 | 0.12 | Basement Membrane Constituent (MIM:156225) |
| LAMA3 | 1.63 | Basement Membrane Constituent (MIM:600805) |
| LAMB1 | 0.50 | Basement Membrane Constituent (MIM:150240) |
| LAMB2 | 2.08 | Basement Membrane Constituent (MIM:150325) |
| LAMB3 | 4.86 | Basement Membrane Constituent (MIM:150310) |
| MMP2 | 1.61 | Extracellular Matrix Protease (MIM:120360) |
| MMP3 | 2.90 | Extracellular Matrix Protease (MIM:185250) |
| MMP7 | 2.37 | Extracellular Matrix Protease (MIM:178990) |
| MMP8 | 0.45 | Extracellular Matrix Protease (MIM:120355) |
| MMP9 | 1.43 | Extracellular Matrix Protease (MIM:120361) |
| MMP10 | 4.59 | Extracellular Matrix Protease (MIM:185260) |
| MMP11 | 0.03 | Extracellular Matrix Protease (MIM:185261) |
| MMP12 | 4.26 | Extracellular Matrix Protease (MIM:601046) |
| MMP13 | 3.82 | Extracellular Matrix Protease (MIM:600108) |
| MMP14 | 1.20 | Extracellular Matrix Protease (MIM:600754) |
| MMP15 | 0.06 | Extracellular Matrix Protease (MIM:602261) |
| MMP16 | 0.42 | Extracellular Matrix Protease (MIM:602262) |
| MMP24 | 0.09 | Extracellular Matrix Protease (MIM:604871) |
| MMP26 | 3.43 | Extracellular Matrix Protease (MIM:605470) |
| TGFB1 | 1.51 | TGF-β Signaling (MIM:190180) |
| TGFB2 | 1.25 | TGF-β Signaling (MIM:190220) |
| TGFB3 | 1.05 | TGF-β Signaling (MIM:190230) |
| TIMP1 | 1.09 | Extracellular Matrix Protease Inhibitor (MIM:305370) |
| VCAN | 1.07 | Cell Adhesion Molecule (MIM:118661) |
| RPL13 | 1.00 | Housekeeping gene (MIM:113703) |
The bold values represent the statistically significant results (fold change ≥ 2 and p-value ≤ 0.05 for upregulated genes, and fold change ≤ 0.5 and p-value ≤ 0.05 for significantly downregulated genes).