Table 1.
The immunolocalization pattern of inflammatory cytokines in the interdental papilla loss site injected with phosphate-buffered saline (PBS) or hyaluronic acid (HA) filler.
| Antibody | Marked Cell | Localization Pattern | |||
|---|---|---|---|---|---|
| PBS Injection | HA Filler Injection | ||||
| Day 2 | Day 7 | Day 2 | Day 7 | ||
| Ki67 | Cell proliferation/nuclear | Basal cells of epithelium, Connective tissue around the injected material | Basal cells of epithelium | Basal cells of epithelium, Connective tissue around the injected material | Basal cells of epithelium |
| IL-1β | Macrophages/fibroblasts | Connective tissue cells | - | Connective tissue cells | - |
| IL-6 | Macrophages/fibroblasts | Very few cells in connective tissue | |||
| TNF-α | Activated macrophages | Connective tissue cells | - | Connective tissue cells | - |
| MPO | Neutrophils | Connective tissue around the injected material | - | Connective tissue around the injected material | - |
IL, interleukin; TNF, tumor necrosis factor; MPO, myeloperoxidase.