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General pathways for the synthesis of berberine derivatives 1–20. Reagents and conditions: (a) Pyridine/NaBH4, rt, 2 h; (b) mCPBA, CH2Cl2, −20 °C, 1 h then Na2SO3, 0 °C, 1 h; (c) 5N NaOH, acetone, rt, 1 h; (d) various bromides, NaI, CH3CN, 80 °C, 4 h.
