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. 2020 Jul 9;20(3):2721–2728. doi: 10.3892/ol.2020.11837

Figure 5.

Figure 5.

Notch2 knockdown abates the effect of exosomal anti-miR-34b on cell proliferation and the EMT in ovarian cancer cells. (A) Relative expression levels of Notch2 in SKOV3 cells co-cultured with IOSE-80, IOSE-80+NC or IOSE-80+anti-miR-34b. (B) Cell viability and (C) cell invasion assays in SKOV3 cells cultured with exosomes isolated from SKOV-3, IOSE-80, IOSE-80+NC or IOSE-80+anti-miR-34b. (D) Relative expression levels of EMT markers (E-cadherin, N-cadherin and Snail) in SKOV3 cells cultured with exosomes isolated from SKOV3, IOSE-80, IOSE-80+NC or IOSE-80+anti-miR-34b. (E) and (F) western blotting of E-cadherin, N-cadherin and Snail in SKOV3 cells co-cultured with IOSE-80, IOSE-80+NC, or IOSE-80+anti-miR-34b. **P<0.01, ***P<0.001 vs. NC-Exos. #P<0.05, ##P<0.01 vs. anti-miR-34b-Exos. EMT, epithelial-mesenchymal transition; NC, negative control; Exos, exosomes; IO, IOSE-80; SK, SKOV3; si, small interfering.