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Effects of the high-fat and high-cholesterol diet and metformin supplementation on testicular (a) cholesterol, (b) testosterone and (c) estradiol levels in the male mice: Data are expressed as means ± SD (n = 5 per group). * p < 0.05 as determined by one-way ANOVA followed by LSD post hoc test. NC, normal diet; HFC, high-fat and high-cholesterol diet; HFC + Met, HFC with metformin supplementation.
