Figure 1.

Schematic overview of C. auris biofilm development and the structure of the antifungal Cm-p5 peptide and its derivatives. (a) Classification of the three major steps in biofilm formation of C. auris. The early phase (4 h) is characterized by the adhesion of planktonic cells to the substratum. Proliferation and extracellular matrix production take place in the intermediate phase (12 h). The mature biofilm features the production of virulence factors and dispersion of planktonic cells from the biofilm (24 h). (b) Structure of the original Cm-p5 and its helical stabilized derivatives. NMR structure shown for the original helical Cm-p5 peptide can be accessed in the RSCB protein data bank (PDB: 2MP9).