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. 2020 Jun 27;8(7):179. doi: 10.3390/biomedicines8070179

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Pathway analysis of the mRNA–miRNA landscapes during the early differentiation period. (A) Experimental design. (B) IPA-generated top canonical pathways (absolute value z-score > 1) (C) miRNA–mRNA interactions of the top transcriptional landscape network. (D) Expression levels of miRNAs targeting the HOXA1 node and its respective expression level at stage 3 (n = 3 samples for controls; n = 6 samples for HNF4α^+/Δ). (E) Expression levels of hsa-miR-214-3p and hsa-miR-3180 and their target SALL4 expression at stage 3 (n = 3 samples for controls; n = 6 samples for HNF4α^+/Δ). Graphs data are shown as mean and SD. * p < 0.05, ** p < 0.01, **** p < 0.0001 (Mann–Whitney test).