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. 2020 Aug 3;10:13065. doi: 10.1038/s41598-020-70000-6

Figure 2.

Figure 2

13C labelling patterns of intracellular metabolites. Mass isotopomer distribution in parental and FHdim cells fed with [1,2-13C]glucose (a) and [U-13C]glutamine (b). Each bar chart and error bar represent the mean and standard deviation from triplicate samples. Panel (c) illustrates how M + 3 fumarate is generated by U-13C glutamine labelling. Abbreviations: Pyr, pyruvate; 3PG, 3-phosphoglyceric acid; PEP, phosphoenolpyruvate; Fum, fumarate; aKG, alpha-ketoglutarate; Mal, malate; Pro, proline; Glu, glutamate; Gln, glutamine; Cit, citrate; OAA, oxaloacetate.