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Auto-inhibitory N-terminal inserts in NOSs (A) and calmodulin-binding domain (B): Insights into controlling Ca2+-dependence and the conservation of calmodulin-binding sites in placozoans. Alignments of selected NOSs was performed using the sequence information from species outlined in Fig. 1. The references for each particular gene and/or their sequences with relevant GeneBank accession numbers are summarized in the supplementary dataset (Excel Table).
