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. 2020 Aug 3;10:13018. doi: 10.1038/s41598-020-70138-3

Figure 1.

Figure 1

VIP serum levels in patients with different thyroid function status. (a) Association between VIP levels and thyroid status. ELISA determinations of VIP serum levels in 78 patients with Hashimoto’s thyroiditis (HT), 144 with Graves’ disease (GD), and 49 healthy donors (HD). (b) Association between VIP serum levels and thyroid function in patients with GD. ELISA determinations of VIP concentration in serum from 73 GD patients at the initial onset of the disease, 36 euthyroid GD patients controlled with antithyroid drugs and 35 GD hypothyroid patients due to treatment iatrogenesis. (c) Association between VIP levels and treatment groups in patients with GD. ELISA determinations of VIP concentration in serum from 73 GD patients with no treatment, 36 treated with anti-thyroid drugs, 21 treated with radioiodine and 14 that underwent surgery. Data are presented as the interquartile range (p75 upper edge of the box, p25 lower edge, p50 midline), p90 (line above the box), and p10 (line below the box) of serum VIP levels. Dots represent outliers. *P < 0.05; **P < 0.01.