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. 2020 Aug 3;10:13016. doi: 10.1038/s41598-020-69495-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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RNA-Seq analysis of IMR90-cardiomyocytes ± menadione and cMSC-conditioned medium. (a) Heatmap of the 3,628 differentially expressed genes (log₂fold change > 2, p value < 0.05) across the four IMR90-CM treatment groups (n = 3), shown by unsupervised cluster analysis. Oxidative stress was induced for 24 h with 20 μM menadione with and without cMSC-conditioned medium treatment. The heatmap was created in SeqMonk using Pearson’s Correlation clustering for the genes (y-axis). (b) Venn diagram showing overlapping genes shared in the pairwise comparisons indicated. Green, up-regulated genes vs untreated; grey, down-regulated genes vs untreated; blue, up-regulated genes vs menadione-stressed; red, down-regulated genes vs menadione-stressed. (c,d) Curated heatmaps and tables of GOs for the changes induced by (c) menadione or (d) cMSC-conditioned medium. Tables include top 5 non-redundant GOs, from the ToppGene “Biological Process” database. For a full list of the generated GOs see Supplementary Fig. S7. These data were deposited on SRA public repository with accession number PRJNA629893.