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. 2020 Aug 3;10:12995. doi: 10.1038/s41598-020-69937-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Dose–response curves for vaginal HIV-1 challenge studies in humanized BLT mice. Plots of efficacy versus dose of (A) VRC01-N (N = 8 per dosing group, 5 groups) and (B) TDF-FTC-VRC01-N combination (N = 10 per dosing group, 5 groups per study; two studies) applied prior to HIV-1 challenge. Open circle corresponds to datapoint from separate experiment. Dashed lines are fits to a sigmoidal dose–response (variable slope) model used to calculate EC₅₀ of the drug or drug combination providing protection against vaginal HIV-1 challenges.