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Schematic representation of series of events involved in the exacerbation of renal injury with MIOX overexpression in the setting of obesity. Hyperlipidemic ambience increases the expression of MIOX. Subsequently there are perturbations in cellular redox potential. Conceivably, this is followed by downregulation of various metabolic sensors and related modulators including p-AMPKα, Sirt1/Sirt3, PGC1-α and YY-1, ultimately leading to an accentuation of renal injury.
