Fig. 2. H-MAGMA identified 263 protein-coding genes linked to ASD.

a Schematic diagram of H-MAGMA. SNP based association P-values were aggregated to gene-based P-values using positional information, as well as chromatin interaction in the fetal brain. b Gene-based association results from H-MAGMA. The x-axis indicates the start position of genes (hg19). c Overlap of ASD risk genes harboring common and rare variants⁷⁴. d Overlapped genes with differential expression from post-mortem brains in individuals with ASD patients and neurotypical controls⁷⁷. e Gene ontologies enriched for ASD linked genes (top 20). f Developmental expression pattern of ASD risk genes¹¹⁸.