Figure 2.

Mice injected with scrapie prions that had been pre-treated with CAC-717 survive longer than those injected with PBS-treated scrapie prions. Shown are the survival curves of Tga20 mice injected intracerebrally with CAC-717-treated Chandler prion-infected ScN2a cell lysate (red line) or the corresponding PBS-treated counterpart (dotted black line). Mice injected with CAC-717-treated prions survived significantly longer as compared with mice injected with PBS-treated prions (log-rank test, p < 0.01).