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Effect of LHMW on tyrosinase activity. α-MSH alone or simultaneously with LHMW was added to B16 cells and cultured for 24 h. The tyrosinase activity was measured, and the average value of the control was expressed as 100% (mean ± SD, n = 6, ***; p < 0.001 vs. control, ##; p < 0.01, ###; p < 0.001 vs. vehicle).
