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. 2020 Jul 8;20(3):2595–2605. doi: 10.3892/ol.2020.11833

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Copyright: © Fu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — Schematic of granule neuron development and the genetic interactions of genes involved in medulloblastoma. (A) Diagram representing the expression and regulation of ATOH1 during granule neuron development. ATOH1 is expressed in granule neuron precursors but not in differentiated granule neurons. (B) Schematic of the medulloblastoma associated gene interaction network of ATOH1. ATOH1 promotes medulloblastoma by up regulating genes such as GLI2 to enhance proliferation and inhibit differentiation. ATOH1, atonal bHLH transcription factor 1; GLI2, GLI family zinc finger 2; SHh, sonic hedgehog; EGL, external granule layer; IGL, internal granule layer; HIC1, hypermethylated in cancer 1; Mycn, MYCN proto-oncogene bHLH transcription factor; Hhip, hedgehog interacting protein; Ccnd1/2, cyclin D1/2; Id1, inhibitor of DNA binding 1 HLH protein; Id2, inhibitor of DNA binding 2; BMP, bone morphogenetic protein; Dlx1/2, distal-less homeobox 1/2; Ptch1, patched 1; PN-1, protease nexin-1.