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. Author manuscript; available in PMC: 2020 Aug 4.
Published in final edited form as: Cancer Discov. 2019 Aug 21;9(11):1574–1589. doi: 10.1158/2159-8290.CD-18-1308

Figure 7: FGFR1 induces ZEB1 and ADAMDEC1 through ERK1/2 signaling.

Figure 7:

(A) Treatment with FGF2 induces phosphorylation of ERK1/2, p38 and STAT3 in control cells, but only ERK1/2 phosphorylation is attenuated by FGFR1 knockdown. (B) ERK1/2 inhibitor SCH772984 blocks phosphorylation concentration-dependently. (C) SCH772984 attenuates ERK1/2 phosphorylation after FGF2 treatment. (D) ERK1/2 inhibition decreases expression of ZEB1 and ADAMDEC1. (E) Diagram depicting the ADAMDEC1-FGFR1-ZEB1 feedback loop.