WT (n=8) and Chrebp KO (n=8) mice were fed either the control diet (CD) or high-fructose diet (HFrD) for 3 days starting at 8 weeks of age; they were then fasted for 2 h to achieve synchronization. Plasma levels of (A) ALT, (B) AST, (C) LDH, (D) triglyceride, and (E) total cholesterol, (F) liver triglyceride, and (G) liver cholesterol were measured from portal samples. Lactate levels in (H) the intestine and (I) liver were measured. Results are expressed as mean ± SEM. * p<0.05 vs. genotype-matched, CD-fed group; #
p<0.05 vs. diet-matched, genotype control.