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. 2020 Jul 10;20(3):2613–2620. doi: 10.3892/ol.2020.11854

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Copyright: © Nweke et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — Schematic of the insulin signalling pathways, including the different genes targeted by (A) downregulated and (B) upregulated miRNAs. Blue and red nodes indicate genes in the pathways determined by the KEGG software to be targeted by dysregulated miRNAs. Of interest, INSR is only targeted by the downregulated let-7 family (red nodes). The figure was generated from the Kyoto Encyclopedia of Genes and Genomes pathways. The nodes (circles) were drawn onto the KEGG-generated figure using Microsoft Powerpoint v2013 to highlight targeted genes. INSR, insulin receptor; miRNA, microRNA; CAP, catabolite gene activator protein; Cb1; cannabinoid receptor interacting protein 1; CRKII, CRK proto-oncogene II; GRF2, general regulatory factor 2; TC10, TC10 protein; EXO70; exocyst complex protein; CIP, Cdc42-interacting protein; GLUT4, glucose transporter type 4; Lar, low antibody response; SHIP2 (INPPL1), inositol polyphosphate phosphatase like 1; SKIP, skeletal muscle and kidney-enriched inositol phosphatase; SOCS (CISH), cytokine inducible SH2 containing protein; PTPIB, peptidylprolyl isomerase B; JNK, c-Jun NH2-terminal kinase; IKK, I-κ B kinase; P13K, phosphoinositide 3-kinase; αPKC, protein kinase Cα; PDK, pyruvate dehydrogenase kinase; SREBP-1C, SREBP-sterol regulatory element binding protein 1C; PRKAA1 (AMPK), protein kinase AMP-activated catalytic subunit α1; ACC, acetyl-CoA carboxylase; FAS, Fas cell surface death receptor; PyK, pyruvate kinase; GK, glycerol kinase; G6PC, glucose-6-phosphatase catalytic subunit; FBP, fructose-1,6-bisphosphatase 1; PEPCK, phosphoenolpyruvate carboxykinase; PGC-1α, peroxisome proliferator-activated receptor γ coactivator 1-α; FOXO1, Forkhead box protein O1; AKT (PKB), protein kinase B; GSK3B, glycogen synthase kinase 3β; GYS, glycogen synthase; PP1, serine/threonine protein phosphatase; PHKA2 (PHK), phosphorylase kinase regulatory subunit α 2; PYG, glycogen phosphorylase; TSC1, TSC complex subunit 1; PDE3, phosphodiesterase 3; PKA, protein kinase; HSL, hormone-sensitive lipase; BAD, BCL2-associated agonist of cell death; RPS6KB1 (P70S6K), ribosomal protein S6 kinase B1; MTOR, mechanistic target of rapamycin kinase; EIF4EBP1 (4EBP1), eukaryotic translation initiation factor 4E binding protein 1; S6, ribosomal protein S6; EIF4E, eukaryotic translation Initiation factor 4E; MNK, mitogen-activated protein kinase (MAPK) interacting protein kinase; ELK1, ETS transcription factor; ERK, extracellular signal-regulated kinase; MEK (MAP2K), mitogen-activated protein kinase kinase; RAF, RAF proto-oncogene serine/threonine-protein kinase; RAS proto-oncogene; GRB2, growth factor receptor bound protein 2; SHC, SHC adaptor protein 1; SOS, SOS Ras/Rac guanine nucleotide exchange factor.

Figure 2. — Schematic of the insulin signalling pathways, including the different genes targeted by (A) downregulated and (B) upregulated miRNAs. Blue and red nodes indicate genes in the pathways determined by the KEGG software to be targeted by dysregulated miRNAs. Of interest, INSR is only targeted by the downregulated let-7 family (red nodes). The figure was generated from the Kyoto Encyclopedia of Genes and Genomes pathways. The nodes (circles) were drawn onto the KEGG-generated figure using Microsoft Powerpoint v2013 to highlight targeted genes. INSR, insulin receptor; miRNA, microRNA; CAP, catabolite gene activator protein; Cb1; cannabinoid receptor interacting protein 1; CRKII, CRK proto-oncogene II; GRF2, general regulatory factor 2; TC10, TC10 protein; EXO70; exocyst complex protein; CIP, Cdc42-interacting protein; GLUT4, glucose transporter type 4; Lar, low antibody response; SHIP2 (INPPL1), inositol polyphosphate phosphatase like 1; SKIP, skeletal muscle and kidney-enriched inositol phosphatase; SOCS (CISH), cytokine inducible SH2 containing protein; PTPIB, peptidylprolyl isomerase B; JNK, c-Jun NH2-terminal kinase; IKK, I-κ B kinase; P13K, phosphoinositide 3-kinase; αPKC, protein kinase Cα; PDK, pyruvate dehydrogenase kinase; SREBP-1C, SREBP-sterol regulatory element binding protein 1C; PRKAA1 (AMPK), protein kinase AMP-activated catalytic subunit α1; ACC, acetyl-CoA carboxylase; FAS, Fas cell surface death receptor; PyK, pyruvate kinase; GK, glycerol kinase; G6PC, glucose-6-phosphatase catalytic subunit; FBP, fructose-1,6-bisphosphatase 1; PEPCK, phosphoenolpyruvate carboxykinase; PGC-1α, peroxisome proliferator-activated receptor γ coactivator 1-α; FOXO1, Forkhead box protein O1; AKT (PKB), protein kinase B; GSK3B, glycogen synthase kinase 3β; GYS, glycogen synthase; PP1, serine/threonine protein phosphatase; PHKA2 (PHK), phosphorylase kinase regulatory subunit α 2; PYG, glycogen phosphorylase; TSC1, TSC complex subunit 1; PDE3, phosphodiesterase 3; PKA, protein kinase; HSL, hormone-sensitive lipase; BAD, BCL2-associated agonist of cell death; RPS6KB1 (P70S6K), ribosomal protein S6 kinase B1; MTOR, mechanistic target of rapamycin kinase; EIF4EBP1 (4EBP1), eukaryotic translation initiation factor 4E binding protein 1; S6, ribosomal protein S6; EIF4E, eukaryotic translation Initiation factor 4E; MNK, mitogen-activated protein kinase (MAPK) interacting protein kinase; ELK1, ETS transcription factor; ERK, extracellular signal-regulated kinase; MEK (MAP2K), mitogen-activated protein kinase kinase; RAF, RAF proto-oncogene serine/threonine-protein kinase; RAS proto-oncogene; GRB2, growth factor receptor bound protein 2; SHC, SHC adaptor protein 1; SOS, SOS Ras/Rac guanine nucleotide exchange factor.