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. 2020 Aug 3;3:421. doi: 10.1038/s42003-020-01119-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Schematic representation of inference of replication timing, direction of fork progression, and replication speed from repliseq data. b Scatterplot showing changes in replication speed with replication timing in MCF7 breast cancer cell line, which shows an increase in replication speed late during replication. Similar results are observed for other cell lines. c Boxplot showing distributions of weight of Signature 8 in replication timing contexts in breast cancer (BRCA-EU), ovarian cancer (OV-AU), and lymphoma (MALY-DE). d Boxplot showing distributions of weight of Signature 8 in combinations of replication timing and speed contexts in breast cancer (BRCA-EU), ovarian cancer (OV-AU), and lymphoma (MALY-DE). p Values for comparisons between fast and slow replication speed in late replication contexts are listed; combined p value for the three cohorts using Fishers method is 3.45e−09. e Boxplot showing distributions of weight of Signature 8 in combinations of replication timing, speed, and direction contexts in breast cancer (BRCA-EU), ovarian cancer (OV-AU), and lymphoma (MALY-DE). See Supplementary Fig. 3 for similar results for other cancer cohorts. p Values for comparisons between left and right replication direction were not significant, when analyzed in the context of combinations of replication timing and speed in the cohorts. See Supplementary Data 1 for description of the cancer cohorts including the number of samples.