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. 2020 Aug 3;3:421. doi: 10.1038/s42003-020-01119-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a PCA plot showing different mutational signatures projected based on their trinucleotide frequencies. Cosine similarity is shown to the right. b PCA plot showing different mutational signatures projected based on their weights in different epigenomic contexts. SBS8 is marked with an arrow. Cosine similarity is shown to the right. c Effect size of selected mutational signatures SBS1, SBS3, SBS5, and SBS8 in late replication contexts relative to early replication contexts in different cohorts. Negative values indicate preferential occurrence in early replication contexts. d Scatterplot showing mean proportion of each signature in late replication against its effect size between early and late replication contexts. SBS8, SBS40, and SBS12 are marked. Whiskers indicate the maximum and minimum values across the cancer cohorts. See Supplementary Data 1 for description of the cancer cohorts including the number of samples.