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. 2020 Aug 3;3:421. doi: 10.1038/s42003-020-01119-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a SBS8 is suspected to arise due to replication errors, and has higher burden in context of late and fast DNA replication. b SBS8 is relatively uncommon in de novo germ line mutations and somatic mutations in nonmalignant tissues, but has progressively increased burden in advanced tumors, which have sustained growth signal, impaired genome maintenance, and/or checkpoint defects.