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. 2020 Aug 3;10:13045. doi: 10.1038/s41598-020-69810-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The effect of pretreatment with ENT (30 mg/kg; p.o.) for 6 days, and VAL (15 mg/kg; p.o.) for 6 days, in CP-treated rats (200 mg/kg; i.p.) single dose on day 5, on (A) the LDH activity and (B) the total protein content and (C) the BNP concentration in BALF. ENT (sacubitril/valsartan), CP (cyclophosphamide), VAL (valsartan). Data are expressed as mean ± SD (n = 6). Multiple comparisons were performed using one-way ANOVA followed by Tukey’s as post hoc test; ^*P < 0.05, versus the control group; ^#P < 0.05, versus the CP-treated group.