Table 2.
Histomorphometrical analysis for the lung tissue of the control and all experimental groups.
| Parameters | Groups | ||||||
|---|---|---|---|---|---|---|---|
| Control | ENT | VAL | CP | ENT + CP | VAL + CP | ||
| IAS | 0.47 ± 0.4 | 0.51 ± 0.5 | 0.53 ± 0.5 | 15.9 ± 2.3*** | 0.34 ± 0.4### | 0.57 ± 0.5### | |
| Area % of interstitial collagen | 1.99 ± 0.7 | 2.3 ± 0.52 | 2.3 ± 0.9 | 32.7 ± 1.9*** | 2.5 ± 0.82### | 2.65 ± 0.8### | |
| % of PAS + ve epithelial cells/bronchi | 2.02 ± 0.41 | 2.9 ± 0.54 | 3.1 ± 0.6 | 67.6 ± 4.2*** | 2.7 ± 0.8### | 3.9 ± 0.9### | |
| Mean number ofCD68 alveolar macrophages /HPF | 2.2 ± 0.85 | 2.2 ± 0.9 | 2.33 ± 0.6 | 24 ± 1.9*** | 2.8 ± 0.43### | 3.8 ± 0.7### | |
| Area % of iNOS immunopositivity/HPF | 0.01 ± 0.01 | 0.02 ± 0.01 | 0.02 ± 0.01 | 36.2 ± 1.5*** | 0.52 ± 0.4### | 1.1 ± 0.4### | |
Data are presented as the mean ± SD (One-way ANOVA followed by Tukey’s multiple comparison test; ***P < 0.001, versus the control group; ###P < 0.001, versus the CP-treated group).