Table II.

Association between clinicopathological parameters and tumoral immune parameters.

	gcCD8+ TILs				TILs				TLSs				TILs-TLSs
Parameters	Low	High	χ2	P-value	Low	High	χ2	P-value	Low	High	χ2	P-value	Low	High	χ2	P-value
Sex
Male	23	19	0.854	0.355	17	32	2.153	0.142	15	34	0.131	0.718	26	23	1.311	0.252
Female	9	4			2	12			5	9			5	9
Age (years)
≤50	6	0	4.841	0.028	4	4	1.713	0.191	3	5	0.140	0.708	5	3	0.648	0.421
>50	26	23			15	40			17	38			26	29
Tumor size
≤5 cm	18	17	1.804	0.179	7	32	7.246	0.007	12	27	0.045	0.832	16	23	2.741	0.098
>5 cm	14	6			12	12			8	16			15	9
Nerve invasion
Yes	12	8	0.043	0.836	14	11	13.140	<0.001	10	15	1.303	0.254	18	7	8.616	0.003
No	20	15			5	33			10	28			13	25
Tumor thrombus
Yes	13	4	3.383	0.066	10	12	3.755	0.053	10	12	2.932	0.087	16	6	7.483	0.006
No	19	19			9	32			10	31			15	26
Nodal metastasis
Yes	20	9	2.932	0.087	16	20	8.139	0.004	12	24	0.098	0.755	22	14	4.763	0.029
No	12	14			3	24			8	19			9	18
Histological grade
I–II	11	16	6.631	0.010	5	25	4.950	0.026	8	22	0.682	0.409	10	20	5.773	0.016
III	21	7			14	19			12	21			21	12
pTN stage
I	9	13	6.053	0.048	2	21	8.072	0.018	6	17	0.642	0.725	7	16	5.399	0.067
II	6	5			5	8			5	8			7	6
III	17	5			12	15			9	18			17	10

Values in bold indicate P<0.05. TILs, tumor infiltrating lymphocytes; TLSs, tertiary lymphoid structures.