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. 2020 Jul 31;6(31):eaaw7313. doi: 10.1126/sciadv.aaw7313

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Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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Fig. 4 — (A) Layout of retroviral complementation experiments with GFP control and/or Gata3. (B) Gata3 expression partially overcomes the DN1 thymocyte block and (C) suppressed the enhanced non-T cell lineages (B and myeloid cell development) after 7 days in the OP9-DL1 culture system. FACS shows representative plots and graphs quantitative data from replicate measurements. (Multiple t test analysis. Error bars represent the SD from two independent experiments.) (D) In vivo complementation [Ly5.2 Tcf1 (WT or KO)–transduced stem cells transplanted into Ly5.1 recipient mice] reveals suppression of B cell development also in the thymus (right) 8 weeks after transplantation but minimal and partial rescue of T cell development in the thymus (left and middle). (Middle: Multiple t test analysis. Right: Paired t test. Error bars represent the SD from three individual mice per group.)