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. 2020 Jul 31;6(31):eaaw7313. doi: 10.1126/sciadv.aaw7313

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Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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Fig. 5 — (A) Layout of retroviral complementation experiments with Bcl11b. (B) Thy1 expression is rescued by Tcf1 deficiency by expression of Bcl11b after 14 days in OP9-DL1 culture (pregated Lin⁻GFP⁺ cells). (C) Bcl11b fully rescues T cell development from Tcf1^−/− stem cells that otherwise are arrested in DN1 (pregated Thy1⁺Lin⁻GFP⁺). (D) Intracellular TCRβ expression can be restored in Tcf1-deficient cells by expression of Bcl11b (pregated Thy1⁺Lin⁻GFP⁺ DN subset). (E) Bcl11b overexpression does not affect myeloid and B cell development. (Two-way ANOVA. Error bars represent the SD from three independent experiments.)