Table 2.
Postoperative change in cfDNA concentration relative to the preoperative level. MAD, median absolute deviation.
| n a | Median ± MAD | Mean | 95% CI | P‐value b | > Mean c | |
|---|---|---|---|---|---|---|
| Colorectal cancer | ||||||
| Week 1 | 12 | 3.6 ± 1.16 | 4 | 2.91–5.28 | 0.0005 | 67% |
| Week 2 | 156 | 2.11 ± 1.25 | 3.89 | 3.01–4.97 | < 0.0001 | 33% |
| Week 3 | 200 | 1.81 ± 1.07 | 2.81 | 2.21–3.66 | < 0.0001 | 23% |
| Week 4 | 48 | 1.23 ± 0.71 | 2.66 | 1.43–4.81 | 0.0005 | 13% |
| Week 5 | 13 | 1.16 ± 0.62 | 1.21 | 0.92–1.51 | 0.2734 | 0% |
| Week 6 | 7 | 1.32 ± 0.75 | 1.43 | 0.87–1.99 | 0.2969 | 0% |
| Bladder cancer | ||||||
| Week 1 | 32 | 7.73 ± 5.74 | 10.26 | 7.75–13.13 | < 0.0001 | 47% |
| Week 2 + 3 | 7 | 11.62 ± 5.07 | 13.13 | 7.8–20.23 | 0.0156 | 71% |
| Week 4 | 23 | 1.79 ± 1.58 | 8.44 | 2.18–19.97 | < 0.0001 | 13% |
| Week 5 + 6 | 16 | 1.51 ± 1.31 | 1.92 | 1.25–2.7 | 0.0577 | 0% |
a
n denotes the number of blood samples taken in the given time period.
b
Statistically significant P‐values (P ≤ 0.05) marked in bold.
c
Proportion of samples with cfDNA increase > mean increase of all postsurgical samples (colorectal cancer: mean = 3, muscle‐invasive bladder cancer: mean = 8).