Table 2.
Associations between adherence to the WCRF/AICR lifestyle score and overall, pre-menopausal, and post-menopausal confirmed breast cancer risk.
| Overall Breast Cancer | Pre-Menopausal Breast Cancer | Post-Menopausal Breast Cancer | |||||
|---|---|---|---|---|---|---|---|
| Cases/No Cases | HR (95% CI) | Cases/No Cases | HR (95% CI) | Cases/No Cases | HR (95% CI) | ||
| WCRF/AICR score, continuous (0–7) for each additional point | Model 1* | 119/10,811 | 0.85 (0.68–1.06) | 67/9904 | 0.92 (0.68–1.24) | 42/3256 | 0.68 (0.47–0.99) |
| Model 2** | 119/10,811 | 0.89 (0.69–1.08) | 67/9904 | 0.94 (0.69–1.27) | 42/3256 | 0.74 (0.51–1.06) | |
|
WCRF/AICR score: ≤ 3 > 3.00-≤ 5.00 > 5.00 |
Model 1* |
9/808 94/8427 16/1576 |
1.00 0.81 (0.41–1.61) 0.55 (0.24–1.27) |
3/786 57/7878 7/1342 |
1.00a 1.00a 0.66 (0.30–1.45) |
5/164 31/2494 6/759 |
1.00 0.31 (0.12–0.81) 0.18 (0.05–0.59) |
| ≤ 3 > 3.00-≤ 5.00 > 5.00 |
Model 2** |
9/808 94/8427 16/1576 |
1.00 0.87 (0.44–1.74) 0.62 (0.27–1.43) |
3/786 57/7878 7/1342 |
1.00a 1.00a 0.67 (0.30–1.47) |
5/164 31/2494 6/759 |
1.00 0.45 (0.16–1.23) 0.27 (0.08–0.93) |
* Model 1: age as underlying time variable in all analyses and all analyses stratified by age (in decades) and recruitment period. ** Model 2: additionally adjusted for total energy (in tertiles), years at university, smoking status (never/former/current), family history of breast cancer (no/yes, after the age of 45 years/yes, up to the age of 45 years), age at menarche (≤ 11 years/12-13/14/≥ 15 years), age at first pregnancy (< 25 years and menopausal status/age < 25 years and nulliparous/age ≥ 25 years and nulliparous/first pregnancy before 25 years/first pregnancy being 30 years old or older), hormone-replacement therapy (yes/no), oral contraceptive use (yes/no), and menopausal status (except in models stratified by menopausal status), and age at menopause (except in models with pre-menopausal women). Models for post-menopausal breast cancer were also adjusted for time since recruitment. a Due to the small sample size of the reference category, the lowest category and the intermediate category were merged together and considered as the reference category.