Figure 2.

Hepatocyte TGR5 does not contribute to regulation of food intake, body weight, or adiposity. (A) Study design. (B) Cumulative food intake and (C) body weight over 7 weeks of high fat diet (HFD) feeding in Tgr5^HEP+/+ and Tgr5^HEP−/− mice. n = 12–16. (D) Body weight at the time of euthanasia; (E) total white adipose tissue (WAT) weight; (F) subcutaneous (SC) and perigonadal (PG); (G) mesenteric (MES) and retroperitoneal (RP) adipose tissue weights; (H) brown adipose tissue (BAT) weights; and (I) gallbladder weight in Tgr5^HEP+/+ and Tgr5^HEP−/− mice treated with Compound 18 (C18) or vehicle (VEH). n = 6–9. * p < 0.05 compared with VEH Tgr5^HEP+/+; ⁺⁺ p < 0.01 compared with VEH Tgr5^HEP−/− by two-factor ANOVA.