Table 4.
Summary of the results according to treatments.
| PN | PN + AGIR | PN + STEP |
p PN vs. Surgery |
p PN vs. STEP |
|
|---|---|---|---|---|---|
| General Data | |||||
| N° Pts | 627 | 320 | 242 | 0.09 | 0.04 |
| N° studies | 13 | 19 | 15 | / | / |
| Male/Female | 242/176 | 155/126 | 120/91 | 0.06 | 0.06 |
| Follow up (mo) | 53.3 ± 41.3 | 36.2 ± 15.9 | 28.4 ± 11.8 | 0.06 | 0.03 |
| GA | 34.3 ± 0.8 | 34.5 ± 0.9 | 34.1 ± 3.8 | 0.66 | 0.87 |
| <24 mo/≥24 mo | 59/41 | 67/33 | 81/19 | 0.001 | 0.0001 |
| Etiology (%) | |||||
| NEC | 29.5 | 15 | 15 | 0.06 | 0.12 |
| Gastroschisis | 17 | 32.5 | 33 | 0.04 | 0.02 |
| Volvulus | 16.7 | 11.8 | 9 | 0.64 | 0.55 |
| Multiple atresias | 17.3 | 24.6 | 26 | 0.29 | 0.24 |
| Hirshprung | 6.2 | 2.5 | 2.4 | 0.66 | 0.56 |
| Combined | 1.6 | 6.8 | 6.6 | 0.18 | 0.27 |
| Other | 3.9 | 0.3 | 0.4 | 0.04 | 0.04 |
| Residual Bowel Anatomy (%) | |||||
| Length BS | 45.7 ± 20.9 | 50.8 ± 22.6 | 57.2 ± 22.0 | 0.74 | 0.68 |
| Length AS | NA | 80.3 ± 33.5 | 90.3 ± 32.5 | UV | UV |
| ICV+ | 48.5 | 16.5 | 26 | 0.003 | 0.10 |
| Colon>50% | 43.8 | 62.5 | 96.2 | 0.007 | 0.001 |
| Age at surgery | 39.4 ± 56.6 | 22.7 ± 21.3 | UV | UV | |
| Outcomes (%) | |||||
| Weaning off PN | 61.6 | 46.2 | 43 | 0.03 | 0.01 |
| Survival | 91.5 | 95 | 94.2 | 0.72 | 0.82 |
| Tx | 5.4 | 7.5 | 9.5 | 0.24 | 0.045 |
| LD | 30.4 | 12 | 14.3 | 0.001 | 0.001 |
| IFALD | 23.2 | 12 | 14.3 | 0.01 | 0.06 |
| Abnormal LFTs | 33/461 (7.1) | NA | NA | UV | UV |
PN: Parenteral nutrition; AGIR: autologous reconstructive gastro-intestinal surgery; STEP: serial transverse enteroplasty; N°: number; GA: gestational age; NEC: necrotizing enterocolitis; BS: before surgery; AS: after surgery; ICV+: ileocecal valve present; UV. Unvaluable; Tx: transplantation; LD: liver disease; IFALD: intestinal failure-associated liver disease; LFTs: abnormal liver function tests; NA: not available.