Effects of Stachys sieboldii Miq. root powder (SS) on hepatomegaly and adiposity. Experimental rats were fed a regular diet (RD) or a high-fat and high-cholesterol (HFC) diet with or without Stachys sieboldii Miq. root powder (SS; 3 or 5%) supplementation for 6 weeks. (A) Relative liver, (B) white adipose tissue (WAT), (C) epididymal adipose tissue (EAT), (D) mesenteric adipose tissue (MAT), (E) retroperitoneal adipose tissue (RAT) and (F) perirenal adipose tissue (PAT). Relative tissue weights were calculated as g/100 g of BW. RD, regular diet; HFC, high-fat and high-cholesterol diet; HFC + 3SS, High-fat and high-cholesterol diet + 3% of Stachys sieboldii Miq. root powder; HFC + 5SS, high-fat and high-cholesterol diet + 5% of Stachys sieboldii Miq. root powder. Values are means ± standard deviation, n = 8. Data were analyzed using one-way ANOVA followed by Tukey’s post hoc test. Means labeled without a common letter differ significantly, p < 0.05.