Effect of S. sieboldii Miq. root powder (SS) on adipocyte size. Experimental rats were fed a regular diet (RD) or a high-fat and high-cholesterol (HFC) diet with or without Stachys sieboldii Miq. root powder (SS; 3 or 5%) supplementation for 6 weeks. The epididymal adipose tissue (EAT) was stained with Hematoxylin and Eosin (HE). Magnification, 100×. The EAT surface area was quantified using the Image J program. (A) Representative EAT images; (B) Quantification of the surface area of EAT. RD, regular diet; HFC, high-fat and high-cholesterol diet; HFC + 3SS, High-fat and high-cholesterol diet + 3% of Stachys sieboldii Miq. root powder; HFC + 5SS, high-fat and high-cholesterol diet + 5% of Stachys sieboldii Miq. root powder. Values are means ± standard deviation, n = 8. Data were analyzed using one-way ANOVA followed by Tukey’s post hoc test. Means labeled without a common letter differ significantly, p < 0.05.