Figure 3.

Effects of 16-week D-allulose supplement on hepatic steatosis-related markers in C57BL/6J mice fed a high-fat diet. (A) Hepatic lipid contents. (B) Liver weights. (C) Hepatic lipid metabolism-related enzyme activities. (D) Masson’s trichrome staining; (E) Plasma GOT and GPT levels; Data are presented as the mean ± SE. Kruskal-Wallis test; * p < 0.05, ** p < 0.01, *** p < 0.001 versus control; ND, normal diet; HFD, high-fat diet (20% fat, 1% cholesterol); ERY (HFD + 5% Erythritol); ALL, (HFD + 5% D-allulose); HMG-CoA reductase, hydroxy-methyl-glutaryl-coenzyme A reductase; ACAT, Acyl-CoA: cholesterol acyltransferase; GOT, glutamic-oxaloacetic transaminase; GPT, glutamic-pyruvic transaminase. Arrow indicates fibrosis signs (blue).