Table 2.
Association of N1-MN + 2Py excretion with risk of all-cause mortality in KTR 1.
| Model |
N1-MN + 2Py Excretion (log2) As Continuous Variable n = 660 |
Sex-Stratified Tertiles of N1-MN + 2Py Excretion 2 | |||||
|---|---|---|---|---|---|---|---|
| T1 n = 219 |
T2 n = 221 |
T3 n = 220 |
|||||
| HR (95% CI) | p-Value | HR (95% CI) | p-Value | HR (95% CI) | p-Value | Reference HR | |
| 1 3 | 0.55 (0.43–0.71) | <0.001 | 2.28 (1.49–3.49) | <0.001 | 1.52 (0.96–2.39) | 0.07 | 1.00 |
| 2 4 | 0.61 (0.47–0.79) | <0.001 | 2.03 (1.31–3.15) | 0.002 | 1.45 (0.92–2.30) | 0.11 | 1.00 |
| 3 5 | 0.60 (0.46–0.78) | <0.001 | 2.13 (1.37–3.33) | 0.001 | 1.51 (0.95–2.40) | 0.08 | 1.00 |
| 4 6 | 0.65 (0.49–0.86) | 0.003 | 1.85 (1.17–2.94) | 0.009 | 1.36 (0.84–2.18) | 0.21 | 1.00 |
| 5 7 | 0.67 (0.52–0.87) | 0.003 | 1.93 (1.23–3.02) | 0.004 | 1.32 (0.82–2.12) | 0.25 | 1.00 |
| 6 8 | 0.69 (0.53–0.90) | 0.006 | 1.74 (1.12–2.72) | 0.02 | 1.42 (0.90–2.25) | 0.13 | 1.00 |
| 7 9 | 0.70 (0.52–0.94) | 0.02 | 1.71 (1.05–2.79) | 0.03 | 1.39 (0.84–2.29) | 0.20 | 1.00 |
| Events (n) | 143 | 66 | 46 | 31 | |||
1 The association of N1-MN + 2Py excretion with risk of all-cause mortality in KTR was investigated with Cox regression analyses, with adjustment for potential confounders. 2 N1-MN + 2Py excretion was <181.3, 181.3–261.2, and >261.2 μmol/day for males, and <147.7, 147.7–216.9, and >216.9 μmol/day for females in T1, T2, and T3, respectively. 3 Model 1: not adjusted in sex-stratified tertiles of N1-MN + 2Py excretion, adjusted for sex in continuous analyses. 4 Model 2: adjusted as for model 1 and for age and body surface area. 5 Model 3: adjusted as for model 2 and for serum hs-CRP. 6 Model 4: adjusted as for model 2 and for plasma vitamin B6. 7 Model 5: adjusted as for model 2 and for eGFR, proteinuria, and primary renal disease. 8 Model 6: adjusted as for model 2 and for use of proliferation inhibitors, acetylsalicylic acid, and proton pump inhibitors. 9 Model 7: adjusted as for model 2 and for intake of alcohol and energy. CI, confidence interval; eGFR, estimated glomerular filtration rate; HR, hazard ratio; hs-CRP, high-sensitivity C-reactive protein; N1-MN, N1-methylnicotinamide; KTR, kidney transplant recipients; 2Py, N1-methyl-2-pyridone-5-carboxamide.