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. 2020 Jul 10;12(7):2059. doi: 10.3390/nu12072059

Table 6.

Association of urinary excretion of N1-MN, 2Py and 2Py/N1-MN, and dietary intake of niacin equivalents with risk of all-cause mortality in KTR 1.

Model Urinary Excretion Dietary Intake
Niacin Equivalents, mg/day 2
N1-MN, µmol/day 2Py, µmol/day 2Py/N1-MN
HR (95% CI) p-Value HR (95% CI) p-Value HR (95% CI) p-Value HR (95% CI) p-Value
1 3 0.53 (0.43–0.65) <0.001 0.59 (0.47–0.75) <0.001 1.06 (1.02–1.10) 0.003 0.58 (0.42–0.81) 0.001
2 4 0.57 (0.46–0.72) <0.001 0.65 (0.51–0.84) 0.001 1.06 (1.02–1.10) 0.005 0.61 (0.43–0.87) 0.006
3 5 0.58 (0.47–0.73) <0.001 0.64 (0.49–0.82) 0.001 1.05 (1.01–1.10) 0.02 0.65 (0.46–0.93) 0.02
4 6 0.61 (0.48–0.77) <0.001 0.69 (0.53–0.91) 0.009 1.06 (1.01–1.10) 0.01 0.65 (0.45–0.93) 0.02
5 7 0.73 (0.57–0.92) 0.009 0.69 (0.53–0.89) 0.004 1.00 (0.95–1.04) 0.85 0.69 (0.48–0.98) 0.04
6 8 0.63 (0.50–0.78) <0.001 0.73 (0.57–0.94) 0.02 1.06 (1.02–1.10) 0.007 0.64 (0.45–0.91) 0.02
7 9 0.64 (0.50–0.82) <0.001 0.74 (0.56–0.98) 0.04 1.07 (1.02–1.12) 0.006 0.77 (0.43–1.38) 0.38

1 The association of urinary excretion of N1-MN, 2Py and 2Py/N1-MN, and dietary intake of niacin equivalents with risk of all-cause mortality in KTR was investigated with Cox regression analyses, with adjustment for potential confounders. 2 HRs per 15 mg increase in dietary intake of niacin equivalents are presented. 3 Model 1: adjusted for sex. 4 Model 2: adjusted as for model 1 and for age and body surface area. 5 Model 3: adjusted as for model 2 and for serum hs-CRP. 6 Model 4: adjusted as for model 2 and for plasma vitamin B6. 7 Model 5: adjusted as for model 2 and for eGFR, proteinuria, and primary renal disease. 8 Model 6: adjusted as for model 2 and for use of proliferation inhibitors, acetylsalicylic acid, and proton pump inhibitors. 9 Model 7: adjusted as for model 2 and for intake of alcohol and energy. CI, confidence interval; eGFR, estimated glomerular filtration rate; HR, hazard ratio; hs-CRP, high-sensitivity C-reactive protein; N1-MN, N1-methylnicotinamide; KTR, kidney transplant recipients; 2Py, N1-methyl-2-pyridone-5-carboxamide; 2Py/N1-MN, ratio of 2Py to N1-MN.