Table 4.
The effect of synbiotic intervention on the severity of IBS symptoms assessed with the use of IBS-SSS score.
| Groups | Baseline (Visit I) | Week 4 (Visit II) | Week 8 (Visit III) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Mean ± SD | Mean ± SD | Change from Baseline | p-Values within-Group |
p-Values Comparison with Placebo |
Mean ± SD | Change form Baseline | p-Values within-Group |
p-Values Comparison with Placebo |
||
| Total IBS-SSS | ||||||||||
| Synbiotic | 318.1 ± 63.6 | 213.8 ± 58.7 | −104.3 ± 88.2 | <0.01 | 0.248 | 148.5 ± 51.2 | −169.6 ± 88.7 | <0.01 | 0.042 | |
| Placebo | 325.5 ± 49.9 | 233.8 ± 81.7 | −91.7 ± 82.0 | <0.01 | NA | 183.7 ± 85.7 | −141.8 ± 95.4 | <0.01 | NA | |
| IBS-SSS 1 (the severity of pain) | ||||||||||
| Synbiotic | 55.7 ± 23.4 | 37.1 ± 21.3 | −18.7 ± 28.8 | <0.01 | 0.878 | 24.9 ± 12.2 | −30.9 ± 24.7 | <0.01 | 0.118 | |
| Placebo | 60.6 ± 20.8 | 37.9 ± 17.8 | −22.7 ± 29.5 | <0.01 | NA | 31.8 ± 22.8 | −28.8 ± 32.5 | <0.01 | NA | |
| IBS-SSS 2 (the frequency of pain) | ||||||||||
| Synbiotic | 32.1 ± 18.5 | 20.3 ± 17.0 | −13.0 ± 28.1 | <0.01 | 0.509 | 12.5 ± 16.3 | −19.6 ± 20.4 | <0.01 | 0.151 | |
| Placebo | 34.8 ± 21.6 | 23.5 ± 21.6 | −11.4 ± 26.6 | <0.01 | NA | 19.7 ± 24.0 | −15.2 ± 29.9 | <0.01 | NA | |
| IBS-SSS 3 (the severity of flatulence) | ||||||||||
| Synbiotic | 63.2 ± 30.2 | 42.4 ± 25.0 | −20.8 ± 32.8 | <0.01 | 0.039 | 23.6 ± 19.1 | −40.1 ± 35.4 | <0.01 | 0.028 | |
| Placebo | 68.2 ± 18.0 | 55.3 ± 25.6 | −12.9 ± 26.6 | <0.01 | NA | 34.1 ± 19.6 | −33.9 ± 29.9 | <0.01 | NA | |
| IBS-SSS 4 (dissatisfaction with bowel habit) | ||||||||||
| Synbiotic | 83.5 ± 19.0 | 58.5 ± 16.3 | −25.0 ± 29.7 | <0.01 | 0.590 | 44.1 ± 21.3 | −39.4 ± 30.0 | <0.01 | 0.135 | |
| Placebo | 80.2 ± 17.1 | 61.1 ± 22.6 | −19.4 ± 22.0 | <0.01 | NA | 52.1 ± 22.0 | −28.4 ± 25.2 | <0.01 | NA | |
| IBS-SSS 5 (quality of life) | ||||||||||
| Synbiotic | 83.5 ± 19.0 | 56.6 ± 17.2 | −26.9 ± 22.7 | <0.01 | 0.913 | 43.4 ± 21.0 | −40.1 ± 25.4 | <0.01 | 0.618 | |
| Placebo | 81.5 ± 17.2 | 56.1 ± 21.2 | −25.4 ± 22.3 | <0.01 | NA | 46.0 ± 21.8 | −35.4 ± 25.0 | <0.01 | NA | |
The severity of IBS symptoms was assessed with the use of IBS-SSS score before treatment (visit I), after 4 weeks (visit II) and 8 weeks (visit III) of the treatment. A score reduction was related to symptom amelioration. The results are presented as a mean ± SD and a change in IBS-SSS score from baseline.