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. Author manuscript; available in PMC: 2020 Aug 4.
Published in final edited form as: Transl Res. 2019 Apr 4;209:68–76. doi: 10.1016/j.trsl.2019.04.001

Figure 4: Lymphedema results in collagen deposition and fibrosis of capillary (upper panel) and collecting (lower panel) lymphatics in a mouse model of tail lymphedema.

Figure 4:

Note accumulation of type I collagen fibers encasing capillary lymphatics in the skin (upper left). Also note proliferation of a-sma positive smooth muscle cells and obliteration of the lumen of collecting lymphatics in lymphedematous tissues (lower left).