Skip to main content
. 2020 Apr 30;39(15):2115–2137. doi: 10.1002/sim.8516

Figure 5.

SIM-8516-FIG-0005b-b

(B): Overview of the second stage of a two‐stage multivariate IPD meta‐analysis to summarize a nonlinear treatment‐covariate interaction using a restricted cubic spline. The steps are described in relation to the hypertension example of Figure 3 which examined a treatment‐age interaction