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. 2020 Aug 4;9:31. doi: 10.1186/s40035-020-00212-3

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Target GCH1 regions with associative results and linkage disequilibrium. The top scatter plot shows the association analysis of P-values in the WGS cohort and degree of linkage disequilibrium (LD) with the lead single variant. The solid line marks the Bonferroni-corrected significance threshold and the dashed line marks the suggestive significance threshold of P < 0.05. In the target regions, gray color depicts the range of eQTLs, blue color depicts regulatory regions, and orange shows transcript region. The bottom plot demonstrates the LD blocks of target regions. *Three variants were not included in the figure because these were in the distal region of present targets and were not associated with PD.