Table 1.

The preliminary in vitro growth inhibition of several cells (IC₅₀, µM) with Largazole and its analog 16c–d.

	IC50 a (µM)
	A549	HCT116	MDA-MB-231	SK-OV-3
largazole	0.52 ± 0.17	0.11 ± 0.01	4.75 ± 1.95	0.25 ± 0.17
16c	2.92 ± 0.53	1.41 ± 0.54	>10	3.13 ± 0.50.
16d	>10	6.62 ± 1.86	>10	>10

^a Compounds were tested in at least seven-dose IC₅₀ mode in duplicate with three-fold serial dilution.