Table 3.
Hazard ratios (HR) and 95% confidence intervals (CI) for cancer mortality by baseline inflammatory biomarkers
| BMI categories | |||||
|---|---|---|---|---|---|
| Normal (18.5≤BMI<25 kg/m2) | Overweight or Obese (BMI≥25 kg/m2) | pint with BMI | |||
| Log Transformed | T3§ | Log Transformed | T3 | ||
| IL-6 (pg/ml), N (Cases) | 454 (29) | 120 (15) | 1368 (54) | 488 (27) | |
| Weighted N (Cases) | 6402 (371) | 1136 (195) | 19904 (937) | 6310 (492) | |
| Crude | 3.3 (1.5, 6.7)** | 5.5 (1.8, 16.4)** | 2.8 (1.6, 4.7)** | 3.2 (1.5, 6.7)* | <0.0001 |
| Model 1 | 3.0 (1.4, 6.3)** | 4.2 (1.5, 11.9)** | 2.8 (1.6, 5.0)** | 3.4 (1.4, 7.0)** | 0.007 |
| Model 2 | 3.2 (1.5, 7.0)** | 5.3 (1.6, 17.8)** | 3.0 (1.7, 5.4)** | 3.5 (1.5, 8.1)** | 0.007 |
| Model 3 | 2.1 (0.8, 5.4) | 2.4 (0.6, 9.0) | 2.6 (1.4, 4.9)** | 2.9 (1.2, 6.6)* | 0.716 |
| IL-8 (pg/ml), N (Cases) | 454 (29) | 168 (12) | 1368 (54) | 436 (25) | |
| Weighted N (Cases) | 6402 (371) | 2101 (187) | 19904 (937) | 6228 (552) | |
| Crude | 1.1 (0.7, 1.8) | 1.8 (0.6, 5.2) | 1.4 (1.0, 2.2)** | 1.5 (0.8, 3.1)* | 0.047 |
| Model 1 | 0.9 (0.5, 1.7) | 1.5 (0.5, 4.2) | 1.4 (0.9, 2.3) | 1.4 (0.7, 2.8) | 0.049 |
| Model 2 | 0.9 (0.5, 1.7) | 1.5 (0.5, 4.1) | 1.4 (0.9, 2.3) | 1.4 (0.7, 2.9) | 0.043 |
| Model 3 | 0.9 (0.4, 1.9) | 1.1 (0.3, 4.4) | 1.2 (0.7, 2.2) | 1.3 (0.6, 2.8) | 0.710 |
| IL-10 (pg/ml), N (Cases) | 454 (29) | 148 (9) | 1368 (54) | 459 (22) | |
| Weighted N (Cases) | 6402 (371) | 2307 (148) | 19904 (937) | 6230 (367) | |
| Crude | 0.7 (0.5, 1.1) | 0.7 (0.3, 1.7) | 1.0 (0.6,1.5) | 1.2 (0.6, 2.2) | 0.006 |
| Model 1 | 0.8 (0.5,1.2) | 0.7 (0.3, 1.9) | 0.9 (0.6, 1.6) | 1.0 (0.5, 2.0) | 0.021 |
| Model 2 | 0.7 (0.5, 1.2) | 0.7 (0.2, 2.1) | 0.9 (0.6, 1.5) | 1.0 (0.5, 2.0) | 0.016 |
| Model 3 | 0.6 (0.4, 1.1) | 0.6 (0.2, 2.6) | 0.9 (0.5, 1.6) | 0.8 (0.4, 1.7) | 0.636 |
| CRP (mg/L), N (Cases) | 678 (31) | 102 (8) | 1368 (54) | 506 (20) | |
| Weighted N (Cases) | 6402 (371) | 1217 (92) | 19904 (937) | 6987 (364) | |
| Crude | 1.7 (1.2, 2.4)** | 3.6 (1.2, 10.4)** | 1.1 (0.8, 1.4) | 1.1 (0.6, 2.2) | 0.0003 |
| Model 1 | 1.6 (1.1, 2.2)** | 3.5(1.1, 11.4)* | 1.1 (0.8, 1.4) | 1.2 (0.6, 2.4) | 0.009 |
| Model 2 | 1.6 (1.1, 2.2)** | 3.4 (1.0, 11.2)* | 1.1 (0.8, 1.5) | 1.3 (0.6, 2.8) | 0.008 |
| Model 3 | 1.6 (1.1, 2.2)* | 4.2 (1.1,16.4)* | 1.2 (0.9, 1.6) | 1.6 (0.7, 3.5) | 0.412 |
Crude model included the exposure and age.
Model 1: Adjusted for age, gender, education, race, and income.
Model 2: Additionally adjusted for exercise
Model 3: Additionally adjusted for smoking status, alcohol use, aspirin use, statin, and comorbidity score
§
T1: 1st tertile, was the reference category; T3: 3rd tertile
Bold indicates significance at 0.05 alpha level.
**
p-values were ≤0.01;
*
p-values were ≤0.05 while the rest of p-values were >0.05.
pint, p for the interaction of the log form with BMI. The p-values are from type 3 tests. P for the interaction is considered significant at alpha=0.1.