Figure 1.

Hazard ratio estimates of overall MACE events associated with INSTI-based regimens versus non-INSTI-based regimens using calendar-time inverse probability of treatment-weighted models.

MACE, major adverse cardiac event; INSTI, integrase strand transfer inhibitor; IPTW, inverse probability of treatment weighted; PS, propensity score. (a) unadjusted model (b) IPTW model using calendar time-specific PS (primary analysis). (c) IPTW model using calendar time-specific PS including additional variable (abacavir) (sensitivity analysis).